Scientists Develop New Method to Control Genome Architecture in Living Cells
A new approach enabling controlled activation of DNA loop extrusion at specific genomic locations is helping scientists understand how genome architecture shapes gene expression. The technique allows researchers to study cohesin’s role in organizing chromatin without disrupting overall genome integrity. This represents a significant advancement over previous methods that relied on global depletion of architectural proteins.
Breakthrough in 3D Genome Research
Scientists have developed a novel system that enables controlled activation of DNA loop formation at specific genomic locations, according to reports in Nature Genetics. This breakthrough approach allows researchers to study how the three-dimensional organization of the genome influences gene regulation without disrupting overall cellular function, sources indicate.