Scientists Uncover Shared Activation Mechanism for Heat and Chemical Sensing in Pain Receptor
Researchers have determined how the TRPM3 pain receptor responds to both heat and chemical stimuli through shared structural transitions. The findings reveal a converged activation mechanism that could inform future pain management therapies.
Structural Breakthrough in Pain Receptor Understanding
Scientists have made significant progress in understanding how the body’s pain detection system responds to multiple stimuli, according to recent research published in Nature Structural & Molecular Biology. The study provides the first detailed structural analysis of how TRPM3, a key pain receptor, is activated by both temperature changes and chemical compounds through a shared mechanism.